Immunophenotyping of Immune Cells in Peripheral Blood of TB Patient with Positive Smear Before Treatment

ABSTRACT Regarding cellular immunity function and macrophage system in tuberculosis infection control and also tuberculosis high spread in Gilan province and as many studies about tuberculosis has done in chronic and acute progressive process. This study was examined thirty persons smear positive with clinical symptoms and recognition infections expert before Treatment. Tuberculosis patients who recieved corticostroid and Immunosupresion drugs or they had another systemic disease and studies were not examined on them. The percent mean which resulted of each cellular surface marker were compared studied patients and PPD+ individuals without clinical symptoms with percent mean markers in healthy individuals. Statistical studies were showed significant increase in the number of PPD+ cells in patients ratio of (P<0.0001) normal and ratio of PPD+ (P<0.01) individuals and significant increase in CD16-56 Marker in patients ratio of (P<0.0001) normal individuals and significant increase in CD8, marker in patients ratio of (P<0.0001) normal individuals and ratio of PPD+ (P<0.01) individuals. Also, it showed significant decrease in PPD+ marker patients ratio of (P<0.01) normal individuals and CD25 patients ratio of (P<0.0001) normal individuals and PPD+ (P<0.02) individuals and meaningful decrease in CD3 marker patients ratio of (P<0.002) healthy individuals. Mean decrease was observed in CD14 marker (monocytic class), but it was not considerable and meaningful occording to statistical studies.